In Baldur's Gate 3, one of the most pivotal decisions awaits players near the story's climax: freeing the imprisoned Githyanki Prince Orpheus or allowing the Emperor to handle the situation. This choice, made after acquiring the Orphic Hammer, significantly impacts the party's fate.

Updated February 29, 2024: Before confronting this choice, players must defeat Ketheric Throm, Lord Enver Gortash, and Orin, exploring Baldur's Gate's upper and lower districts. This decision carries immense weight; companions might sacrifice themselves. High skill checks (potentially 30) are needed for certain interactions to influence companion choices.
Spoiler Warning: The following discusses the game's ending.
Should You Free Orpheus?

The decision hinges on player preferences. The Emperor warns that freeing Orpheus risks party members becoming Illithids (Mind Flayers).
After the Netherbrain encounter (in the Astral Prism), the choice is presented: free Orpheus or let the Emperor absorb his power.
Side with the Emperor: This leads to Orpheus's demise as the Emperor absorbs his knowledge. Lae'zel and Karlach may disapprove, impacting their personal quests. While this aids in defeating the Netherbrain, it may not appeal to all players.
Free Orpheus: This causes the Emperor to ally with the Netherbrain. A party member might become a Mind Flayer. However, Orpheus joins the fight alongside the Githyanki. He'll even willingly become a Mind Flayer to save his people if asked.
In short: Choose the Emperor to avoid becoming a Mind Flayer; choose Orpheus to risk it. The Emperor's choice might alienate Lae'zel and send Karlach back to Avernus. The ultimate decision rests with the player.
Moral Considerations:
The moral high ground depends on individual perspectives, but loyalty is key. Orpheus, a rightful Githyanki ruler, opposes Vlaakith's tyranny. A Githyanki player might naturally side with him. However, following Voss and Lae'zel's demands might seem overly forceful to others. The Gith prioritize themselves, even if their actions affect the wider world.
The Emperor is generally benevolent, aiming to stop the Netherbrain and aid the party. He accepts that sacrifices are sometimes necessary. Following his plan might result in a Mind Flayer transformation, but a morally upright one. Remember, BG3 offers multiple endings; strategic choices can lead to favorable outcomes for everyone.